1. Configure below parameter in instance profile.is the numbering sequence. If the PROT=SMTP is already exist, just leave it there. If not, create a new parameter using the below parameter. You can create via transaction code RZ10. After created, please restart the SAP to apply the changes.
icm/server_port_<xx> = PROT=SMTP,PORT=2500
2. Execute transaction code SCOT. Go to Settings > Default Domain. The Default Domain should be enter by <company-name>.com. Do not include http:// or www
3. On transaction code SCOT, double click on SMTP and ensure Node in use is tick and SMTP Connection for Mail Host and Mail Port is filled.
4. Under Supported address types, click on Set for Internet. Under Address area, put * to permit all outgoing emails.
5. Next, we need to schedule the job that will periodically send the emails. Still in transaction code SCOT, select View > Jobs. If the job already scheduled, you will the screen below. If not, you need to create the job. The job name will be RSCONN01 and select variant SAP&CONNECTALL. The job need to be run periodically, as example every 5 or 10 minutes. The scheduler (user) need to have profile S_A.SCON enabled.
Note:
http://help.sap.com/saphelp_nw04/helpdata/en/af/73563c1e734f0fe10000000a114084/content.htm
